Prime Big Deal Days runs October 6–7, 2026 — 48 hours only. This list has 43 items curated by Sasha Z, covering everything from fashion to skincare to kitchen appliances. The Karl Lagerfeld Camilla Loafer at 33% off ($107, was $159) is the most significant fashion deal on the list. The Sunday Riley serums and the full Remedy Science line from dermatologist Dr. Shah are the skincare standouts. The Thayers toner collection gives you the full toner library in one place. Scroll by category — or use the quick links below to jump straight to what you're shopping for.
Fashion —
Up to 59% Off
Trendy Queen matching sets · ZITY flannel shirts · wide-leg jeans · cardigans · cowboy boots · all with free Prime shipping
Shoes —
The Karl Lagerfeld Deal
Karl Lagerfeld Camilla Loafer 33% off · DREAM PAIRS platform chunky loafer · CUSHIONAIRE leather penny loafer
Beauty —
MISSHA, Maybelline & Wavytalk
MISSHA glow sunscreen · Maybelline serum lipstick · Wavytalk 5-in-1 blow dry brush
Thayers —
The Full Toner Edit
Six Thayers products · from $6.99 · witch hazel, rose petal, oat milk, snow mushroom, AHA pads and blemish pads
Thayers is one of the most-recommended toner brands on Amazon — the witch hazel-based formula has been a skincare staple for decades. Prime Day has the full line at reduced prices. Here's the quick breakdown of which is for whom.
Which Thayers to buy: Dry/sensitive → Milky Mist or Snow Mushroom. Normal skin → Rose Petal (the classic). Fragrance-sensitive → Unscented. Oily/congested → AHA Pore Pads. Breakout-prone → Salicylic Acid Blemish Pads. All are under $11 on Prime Day.
Sunday Riley —
The Prestige Skincare Deals
30% off for Prime Big Deal Days · Good Genes · CEO Afterglow · CEO Glow · Pink Drink · A+ Retinol · 48 hours only
30% off for Prime Big Deal Days — 48 hours only. All five products below are 30% off October 6–7 only. Good Genes drops to $59.50, CEO Glow to $28, Pink Drink to $33.60, CEO Afterglow to $45.50, A+ Retinol to $59.50. Stock up if you've been waiting for a sale.
Sunday Riley is one of the most respected prestige skincare brands in the $40–$100 range — the kind of brand where the products genuinely do what they say. Four pieces from their lineup are in Sasha's Prime Day list, covering brightening, vitamin C, lactic acid, and resurfacing.
Remedy Science —
The Dermatologist's Line
20% off for 48 hours · select products · dermatologist Dr. Shah's formulas · Azelaic Acid, Vitamin C, Eye Cream, Barrier Cream + hand care
Remedy Science is a dermatologist-developed skincare line — the brand for someone who wants clinically-informed formulas at accessible prices. Seven products from the REMEDY line are in Sasha's Prime Day list, covering every step of a morning and evening routine. At $17–$35 per product this is significantly more accessible than comparable dermatologist-recommended brands.
Prime Day 20% off — 48 hours only: The Azelaic Acid ($19.99), Vitamin C ($22.39), Eye Cream ($16), and Barrier Cream ($15.99) are all 20% off. Also on sale but not listed here: the Multi Depth Moisture Advanced Hydrating Serum, Hand & Cuticle Firming Whipped Cream with Peptides, and Hand & Cuticle Repairing Butter Cream with Retinol — search REMEDY Science on Amazon with your Prime account to see the full 20% off selection.
The Remedy Science starter routine: Cream-to-Foam Cleanser ($17.99) → Vitamin C Complex AM ($27.99) → Azelaic Acid PM ($24.99) → Barrier Repairing Cream ($19.99). That's a complete morning and evening routine for under $90 total, formulated by a dermatologist. Add the Copper Peptide and Dark Spot Serum as the next step up.
Home & Kitchen —
Ninja & Yankee Candle
Ninja Crispi Pro Glass Air Fryer 17% off · Ninja FrostVault Cooler 20% off · Yankee Candle Spiced Pumpkin Early Prime Deal
Tech —
Echo Dot & Belkin Earbuds
Amazon Echo Dot Kids 56% off · Belkin SoundForm Nano 2 earbuds 20% off